PATHOPHYSIOLOGICAL ASPECTS IN HYPER-AND HYPOKALEMIA
Abstract:
Potassium, the most abundent intracellular cation is essential for the life. Potassium is obtained through the diet. Gastrointestinal absorption is complete, resulting sometimes an excess intake of about 1mEq/kg/day (60-100 mEq). This excess is excreted through the kidneys (90%) and the gut (10 %). Potassium homeostasis is maintained predominantly through the regulation of renal excretion. The most important site of regulation is th cortical collecting tubule, where aldosteron receptors are present. The importance of potassium in the human body is reflected through the main role in the rest potential, in the ionic and fluid ballance and in the pH ballance. The potassium disorders can determine severe, sometimes life-threatening clinical situations. We propose to present the pathological mechanisme that appears in the potassium disordes.
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