CEACAM1 - A PROMISING BIOMARKER FOR MELANOMA
Abstract:
Malignant melanoma is the third most common skin cancer, but it also remains the most
aggressive. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a promising
diagnostic and prognostic biomarker for melanoma, because its expression is important for tumour
development. This review aims at highlighting the most recent discoveries regarding CEACAM1 and
its correlation to the diagnosis and prognosis of malignant melanoma. National Library of Medicine
(NIH) PubMed was used for selecting articles published between 2004-2021, based on their relevance
and novelty. With its multiple and somewhat contradictory effects, CEACAM1 seems to influence
melanoma invasion, migration, immunomodulation and tumour suppression, serving as a useful
diagnostic biomarker and target for therapy. While the incidence of malignant melanoma has been
increasing over the last decades without signs of prognosis improvement, it is crucial that new
biomarkers for diagnosis and detection of metastatic progression are discovered, and CEACAM1
might be a viable option.
full text article in English (.EN) |