ANALYSIS OF RAS-ONCOGENE MUTATIONS IN LARYNGEAL SQUAMOUS CELL CARCINOMA CYTOLOGICAL SAMPLES OF NORTHERN ROMANIAN DESCENT
Abstract:
The applicability of the Ras-gene family isoforms in cancer research has been
documented for several malignancies but remains limited in head and neck cancers. This is
the first study to attempt an examination of Ras-gene mutations in laryngeal squamous cell
carcinoma (LSCC) subjects of Romanian descent. Analysis using Real-time PCR techniques
identified Ras-mutations in only 11 of the 56 cytological samples, while the prevalent form of
mutation was the K-Ras isoform (73%). Both K-ras and N-ras isoforms were more frequent in
males (P=0.015064) and tended to favour advanced clinical stages (T3/T4) while having a
strong preference for better histological outcomes (P=0.000057 K-ras/ P= 0.010362 N-ras).
In conclusion, the results of the study suggest that mutations within the Ras-gene
protooncogene family appear to favour male subjects and more advanced clinical stages of
LSCC, but with the possibility of a better long-term prognostic in terms of supplementary
histological risk criteria
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