Mechanical stress due to flexion-extension in the femoropopliteal space may cause stent failure via stent fracture and thrombosis. Wire-Interwoven self-expanding Nitinol Stents design partially mimics the reticular structure of native vessels, emphasizing radial strength, flexibility and kink resistance; these stent features can offer more chances for short and long term patency. We have evaluated 5 patients with peripheral artery disease with significant superficial femoral artery or proximal popliteal artery lesions. All patients underwent endovascular therapy with Wire-Interwoven self-expanding Nitinol Stents, with primary focus on stent patency at follow-up visits (1, 6, 12 months). The endovascular initial success was achieved in all 5 patients. Stent patency at 1-year follow-up was achieved in 3 patients (60%). 2 patients (40%) had stent thrombosis within 30 days after procedure secondary to arterial dissection at distal stent extremity and self-withdrawal dual antiplatelet therapy; subsequently target lesion revascularization with endovascular therapy and ilio-femoral bypass was performed.