Lichen planus is an autoimmune, itching disorder that involves T lymphocytes, which may interest the skin, mucous membranes and exoskeletons. The presence of lichen manifestations both at the skin, mucous membranes and at the level of the skin attachments (hair and nails) is rarely mentioned in the literature. Although lichen planus may have a self-limiting evolution, early treatment is important in shortening the evolution of the disease and in controlling the symptoms. The therapeutic effects of retinoids (immunomodulatory, anti-inflammatory, anti-proliferative effects) make them an appropriate choice in the treatment of lichen with (cutaneous-mucosal, nail and planopilaris lesions. We will present the cases of 2 patients with muco-cutaneous, nails and scalp disorder due to lichen planus, and the time of presentation to the doctor made the difference between the complete remission of the disease and the evolution towards severe, extended, definitive alopecia in the scalp and genital lichen sclerosus.