BREAST CANCER RISK ASSESSMENT MODELS. OVARIAN ABLATION AND HORMONAL CHEMOPROPHYLAXIS
Abstract:
Breast cancer is the most common form of cancer that affects females, during lifetime, 1 of 8, 1 in 12 (1) develops this type of cancer. Breast cancer incidence is steadily rising; genetic studies show that over the last 80 years there has been a three-fold increase in incidence both in the general population and at high-risk population (those showing BRCA 1, BRCA2 gene mutations). The incidence of breast cancer newly diagnosed in women of all ages in Romania in 2018 according to Globocan is 21.5% (9269 new cases diagnosed).(3) The Gail and Claus models are the most commonly used prediction models regarding breast cancer risk due to the high predictive value in assessing estrogen-receptor-positive (ER+). Therefore, it is necessary not only to establish a degree of prediction of the disease through these assessment models, but also to apply hygienicdietary measures, namely the initiation of prophylactic therapy, in order to prevent the disease. The interpretation of the Gail model, if the patient has a risk ≥ = 1.66%, is eligible for chemoprevention therapy with hormonal agents over the next 5 years.(4)
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