MULTIMODAL THERAPY FOR PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER A RETROSPECTIVE STUDY ON PATIENTS TREATED AT CLINICAL COUNTY HOSPITAL OF SIBIU, BETWEEN 2012-2016
Abstract:
Objective: To indentify management strategies in patients with locally advanced prostate
cancer receiving multimodality therapy at Clinical County Hospital of Sibiu, from January 2012 through
December 2016. Methods: the study included 179 patients with locally advanced prostate cancer who
were treated by radical prostatectomy (RP), radiotherapy with adjuvant androgen deprivation therapy
or neoadjuvant androgen deprivation therapy (ADT) followed by adjuvant ADT, or only hormone
therapy. Trends in multimodality therapy were assessed over time to identify treatment patterns in
locally advanced prostate cancer. Results: 116 (65%) patients were treated with radiotherapy, external
beam radiotherapy (EBRT). 13 patients with better performance status, no IRM nodes enlargement had
radical prostatectomy (RP). Neoadjuvant hormone therapy before radiotherapy was the treatment in 9
(5%) of these 179 patients; all of them, received adjuvant hormone therapy after RT. Of the 41 (23%)
patients treated with primary hormone therapy alone, combined androgen blockade was the treatment in
22 (54%) and 19 (46%), had analogues LHRH alone or Bicalutamide alone. Conclusion: treatment for
advanced non-metastatic prostate cancer is a multimodality approach. Radiotherapy with adjuvant ADT
may be considered the standard therapy for these patients.
full text article in English (.EN) |