PROGNOSTIC FACTORS OF LOD EFFICACY IN INFERTILITY TREATMENT OF PCOS
Abstract:
To establish the prognostic factors of LOD positive response in infertility treatment of PCOS. Materials and methods: There were analysed 138 clinical cases of patients who were selected according to Rotterdam criteria regarding PCOS, who were hospitalized in the Department of Aseptic Gynecology no.1 at the Municipal Clinical Hospital N.1 of Chişinău city. Results: Age is an important criterion of prognosis. The rate of success is significantly higher in patients of age till 35 years, (p=0,79, χ ²=11,738). Obesity BMI >30 kg/m2 represented a rate of ovulation more reduced p < 0,01 comparing with those with a BMI (26 – 29) - 18%. In patients with T > 4,5nmol/l, ovulation rate is – 13% that meant (p< 0,05) less than ovulation rate - 20,2% in women with T slightly high 2,6- 4,4nmol/l. Patients with normal T < 2,6 represented a more successful (p<0,01) (ovulation rate - 42,3%) as against the other groups. LH level has a significant impact: the patients that answered after LOD had LH concentrations pre-treatment ≥ 10UI/l (p=0,29, χ ²=20,862, p<0,001) than those that had less LH< 10UI/l, before LOD. Conclusions: The rate of LOD success correlates with the following criteria: age, the length of infertility, BMI, LH, T.
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