EFFECT OF PROBIOTICS ON ALLERGIC IMMUNOPROFILE
Abstract:
Several experimental results have lead to the theory that the pathogenesis of allergic diseases is determined by an imbalance between Th1/Th2 immune responses. It has been founded a Th2 immune response in most of the allergic diseases, which are defined by high levels of interleukin 4 (IL-4). Most of the studies have shown that decreasing Th2 cells cytokines by growing Th1 responses may be a positive switch against Th2 diseases like asthma and allergy. There are some results that confirm that probiotics might have a beneficial effect against allergic diseases by reducing TH2 cytokine production. Consequently, probiotics could restore the host capacity to limit the response against aeroallergens and the development of allergy. The results are very promising, and there is some experimental evidence from animals and humans to suggest their effectiveness. Basic science studies on each probiotic strain that includes their effects on the immune system followed by systematic evaluation of the effects of the most promising strains in specific allergic diseases are required before we can draw any definite conclusions regarding their effectiveness.
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