CHRONIC KIDNEY DISEASE AND OXIDATIVE STRESS
Abstract:
Chronic kidney disease (CKD) is a persistent kidney injury and glomerular filtration rate is
used to identify and classify patients. People with CKD have a high risk of death from stroke or heart
attack and CKD may also progress to total and permanent renal failure (end-stage renal disease), in
which case dialysis or transplantation is then necessary. CKD is associated with cardiovascular risk
factors and non-traditional risk factors, such as inflammation and oxidative stress. Excessive reactive
oxygen species production and/or inadequate antioxidant systems lead to oxidative stress. Oxidative
stress seams to increase as CKD progresses and correlates significantly and inversely with the level of
glomerular filtration rate.
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