PATHOGENESIS OF GASTRIC ADENOCARCINOMA
Abstract:
Gastric cancer occurs consecutively carcinogenic events triggered by a number of etiologic
factors, among which stand Helicobacter pylori infection, associated with about 80% of gastric
adenocarcinomas. If intestinal type gastric cancer appears on a modified gastric mucosa, the presence
of atrophic gastritis with intestinal metaplasia being a necessary condition, the histological substrate of
the diffuse type is not the formation of glandular and ductal structures but undifferentiated tumour cell
invasion. Both gastric cancers associate genetic abnormalities, some consistently documented by
numerous studies, others are still in controversy
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