THE INVOLVEMENT OF HEPATITIS VIRUSES IN THE PATHOGENESIS OF HODGKIN MALIGNANT LYMPHOMAS. EPIDEMIOLOGICAL DATA AND PATHOGENETIC MECHANISMS
Abstract:
Viral infections proved to have an important role in oncogenesis, particularly in developing countries. The infection with hepatitis B or C was identified to be an important pathogenetic factor in the pathogenesis of chronic lymphoproliferative malignancies, especially malignant Hodgkin lymphoma (NHL) cell B. The most common types of NHL identified in the HCV seropositive patients were: NHL diffuse large B cell marginal zone NHL. HBV infection is associated with a higher incidence of clinically aggressive NHL, although HBV infection was less identified in patients with NHL than HCV infection. Recently, it was shown the possible association between the risk of NHL and hepatitis G infection, infected carriers of this virus having an increased risk of being diagnosed with NHL diffuse large cell B. In literature, there are three mechanisms of the involvement of hepatitis virus infection in the NHL pathogenesis. 1. Immunosuppression due to chronic lymphoproliferative neoplasia that could cause reactivation of viral B or C infection. 2. Transmitting and unknown virus with a pathogenic mechanism similar to the hepatitis virus and which might act as an oncogenic stimulus. 3. The existence of a causal relationship between the infection with the hepatitis virus and NHL, the hepatitis playing an oncogenic role. More recently, it is taken into consideration the involvement in lymphomagenesis, a multi cause mechanism involving the convergent action of at least two factors.
full text article in Romanian (.RO) |
full text article in English (.EN) |