INVESTIGATION OF BRONCHIAL HYPER-REACTIVITY. ECRHS II TEST QUESTIONNAIRE VERSUS HISTAMINE PD20 FEV1
Abstract:
Bronchial hyperreactivity (BHR), common in asthma occurs in other diseases such as chronic airway obstruction. Our aim is the validation of the ECRHS II questionnaire (The European Community Respiratory Survey II) in detecting BHR. Methodology: ECRHS II questionnaire was applied on a group of 278 patients with respiratory symptoms, without asthma and was correlated with: smoking index, allergy tests and nonspecific bronchial challenge test with histamine (PD20 FEV1). Results: The PD20 FEV1 test was positive in 85.2% of subjects, the most common symptoms were: wheezing (48% in positive and 15% in negative subjects, with a statistically significant difference), morning chest tightness and sudden shortness of breath. There was no relation between PD20 FEV1 test and atopic status or smoking index. Conclusions: Subjects with wheezing, chest tightness or attacks of shortness of breath after a strenuous effort have BHR with high probability. The combination of the three symptoms certifies BHR’s presence.
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